Kisspeptin Signaling in Reproductive Biology Kauffman Alexander S.
Kisspeptin Signaling in Reproductive Biology Kauffman Alexander S. Kisspeptin has been shown to be both necessary and sufficient for activation of the reproductive axis, during puberty and later in…
Specifikacia Kisspeptin Signaling in Reproductive Biology Kauffman Alexander S.
Kisspeptin Signaling in Reproductive Biology Kauffman Alexander S.
Kisspeptin has been shown to be both necessary and sufficient for activation of the reproductive axis, during puberty and later in adulthood. Kisspeptin has been deemed the single most potent stimulator of GnRH neurons yet known. This makes kisspeptin a fundamental component of the reproductive axis.
Importantly, kisspeptin neurons seem to mediate many of the regulatory effects of other signals, whether they are metabolic, circadian, hormonal, or stress. The importance of kisspeptin has been documented in humans as well as non-human animal models, ranging from monkeys, sheep, and rodents to numerous fish species, thus signifying a highly conserved nature of its reproductive function. This places kisspeptin neurons in a unique position to be key nodal points and conduits for conveying numerous endogenous and exogenous signals to the reproductive
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