Pharmaceutical Biocatalysis: Important Enzymes, Novel Targets, and Therapies Grunwald Peter

This volume of Pharmaceutical Biocatalysis starts with a discussion on the importance of biocatalytic synthesis approaches for a sustainable and environmentally friendly production of pharmaceuticals and active pharmaceutical ingredients. Isocitrate dehydrogenase 1 and 2 mutations are novel therapeutic targets in acute myeloid leukemia. Among the enzymes discussed in detail with respect to their pharmaceutical relevance are cyclic nucleotide phosphodiesterases playing an important role in modulating signal transduction in various cell types; human DOPA decarboxylase, related to Parkinson's disease and aromatic amino acid decarboxylase deficiency; and phospholipase D enzymes as drug targets.

The other topics include small-molecule inhibitors targeting receptor tyrosine kinases in An additional chapter is devoted to the use of enzymes for prodrug activation in cancer therapy.