Vaccine Efficacy Evaluation: The Gnotobiotic Pig Model Yuan Lijuan
Vaccine Efficacy Evaluation: The Gnotobiotic Pig Model Yuan Lijuan Testing the immunogenicity, protective efficacy and safety in animal models is a crucial step in vaccine development. The Gn pig…
Specifikacia Vaccine Efficacy Evaluation: The Gnotobiotic Pig Model Yuan Lijuan
Vaccine Efficacy Evaluation: The Gnotobiotic Pig Model Yuan Lijuan
Testing the immunogenicity, protective efficacy and safety in animal models is a crucial step in vaccine development. The Gn pig model is a widely accepted model for studying pathogenesis and immunity and an ideal model for pre-clinical testing for the safety and efficacy of enteric viral vaccines. Pigs raised in germ-free environments, called gnotobiotic (Gn) pigs, are one of the most useful animal models for testing vaccines.
This book provides detailed information on establishing Gn pig models, determining a proper virus inoculum pool and challenge dose, measuring protection and calculating efficacy, and delineating intestinal and systemic immune responses associated with the protection.Key Through these studies and others, the Gn pig model has been established as the most reliable animal model for pre-clinical evaluation of human rotavirus and norovirus vaccines.
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